ANALGESIC EFFICACY OF ETHANOL LEAF EXTRACT OF JUSTICIAINSULARIS (T. ANDERS)

Abstract

The ethanolic leaf extract of Justiciainsularis (T. Anders) was evaluated for its analgesic properties using acetic acid-induced writhing and thermal (hot plate methods. Acytylsalicycli acid (ASA) 100mg/kg body weight/per day was used as standard drug. Phytochemical screening of the plant extract gave positive test for saponins, alkaloids, tannins, Flavoniriodsanthraquinones and cardiac glycosides. The extract was dose-dependent and significantly at (P = 0.05). The median Lethal dose (LD₅₀) was determined by intraperitoneal route which was calculated to be 2,449.49mg/kg using Lorke method. The experimental design used was a complete randomized type for the studied parameters. The result further justified the use of Justiciainsularis in herbal medicine for treatment of pains.