Exploring Flavonoid Extracts from Medicinal Plants: Assessing their Anti-Cancer Efficacy on Colon Cancer

Abstract

In order to effectively treat colon cancer, which is the most common kind of cancer that results in mortality globally, novel therapeutic techniques are required. In this empirical study, the anti-cancer potential of flavonoid extracts from medicinal plants is investigated, with a particular focus on colon cancer. Our research begins with a comprehensive review of the global burden of colon cancer and the limitations of current treatments. We emphasize the growing interest in natural compounds, specifically flavonoids, as potential game-changers in cancer research and therapy. Medicinal plants renowned for their flavonoid content were chosen, and extracts meticulously prepared. Thorough phytochemical analyses identified specific flavonoids. In vitro experiments using colon cancer cell lines revealed concentration-dependent cytotoxicity, substantiating the potent anti-proliferative effects of the extracts. Flavonoid extracts induced apoptosis, as demonstrated by Annexin V/PI staining and caspase activation assays. Mechanistic insights unveiled their modulation of key apoptosis-related pathways. The present study provides compelling evidence of flavonoid extracts' anti-cancer potential against colon cancer. These findings highlight the significance of natural compounds in cancer research, offering promise for innovative therapeutic strategies. Further investigations and clinical trials are warranted to harness the full potential of flavonoid-based therapies in colon cancer management, potentially transforming the landscape of cancer treatment.