Mortality Pattern of E.coli PB-176 and its Transconjugants Harbouring Different Plasmids in Experimental Swiss Mice

Abstract

The experiment conducted in Division of Microbiology CDRI, Lucknow All the seven haemolytic, drug resistant strains of PB-176, were tested for virulence in mice along with parent strain E.coliPB-176 (R^-hly^-). Four different dilutions of varying number of bacteria of each strain were inoculated intraperitoneally to 24 swiss mice in each batch. The mortality was observed upto ten days. The mortality at the 0.17x10⁸ cells/mouse R⁺hly⁺ strain was 91.6% and (88.8, 85.8, 88.8, 91.6, 88.8 and 84.5%) respectively. While at the dose 0.11x10⁸ cells/mouse the mean mortality for the same was 67.9% and (62.5, 59.6, 58.3, 56.6, 62.5 and 60.8%) respectively.