SYNTHESIS AND EVALUATION OF SOME CHALCONES AND THEIR DERIVATIVES AS ANTIMICROBIAL AGENTS

Abstract

The Study deals with the characterization of antibacterial and antifungal activities of some chalcones and their derivatives. A series of chalcone derivatives of biological interest were prepared, by Claisen-Schmidt condensation of appropriate acetophenones with aromatic aldehydes in the presence of aqueous sodium hydroxide and ethanol at room temperature. The Investigation of the antibacterial growth using the disc method was highly sensitive and effective. All the compounds were tested for their antibacterial and antifungal activities by the disc method. The Physical constant measurement and UV spectra support the materialization of chalcones and their derivatives.