ACTIVITY OF TERMINALIA SERICEA BARK METHANOLIC EXTRACT AGAINST DIABETIC IN ALLOXAN INDUCED DIABETIC ALBINO RATS

Abstract

In normal and alloxan induced diabetic rats the antidiabetic activity of bark methanolic extract of Terminalia sericea was investigated. The present study of animals was divided in to normal control, diabetic control, diabetic treated and control treated group. The effects of oral supplement of T. sericea (100 mg/kg and 200 mg/kg ) for 30 days on the level of blood glucose, total cholesterol, total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL), histological studies and statistical analysis in normal and alloxan-induced diabetic rats were calculated. Comparing the values of T. sericea bark methanolic extract treated group with the control diabetic group, the result found that the bark methanolic extract of T. sericea significantly decreased the elevated blood glucose level, cholesterol, triglycerides, phospholipids, LDL, VLDL and it showed a significant increase in liver HDL level. These results indicated that bark methanolic extract of T. sericea possesses anti-diabetic effect in diabetic rats.