Synthesis And Antimicrobial Evaluation of some Novel (5Z)-5- (4-substitutedbenzylidene)-2- (4-nitrophenyl)[1,3] thiazolo [3,2-b] [1,2,4] triazol-6- (5H)-one derivatives

Abstract

A series of [1,2,4] triazol-6- (5H)-one derivatives[A_1-9] has been synthesized by the cyclization of the 1-acyl-thiosemicarbazide (1) in alkaline medium followed by acidification with 37% HCl gives 5- (4-nitrophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (2). Mixture of 5- (4-nitrophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (2), chloroacetic acid, required aromatic aldehyde, anhydrous sodium acetate, acetic anhydride and acetic acid was refluxed for 6 hr. which gives (5Z)-5- (4-substitutedbenzylidene)-2- (4-nitrophenyl)[1,3] thiazolo[3,2-b] [1,2,4] triazol-6- (5H)-one derivatives (A_1-9) The crude products were recrystallized from methanol.